Pain in the epigastric region, caused by inflammation of the mucous membranes, is often accompanied by peptic ulcers, but they can also be situational heartburn due to increased acidity of the stomach. In such a situation, pharmacists and doctors recommend taking the drug category antacids. In particular, little-known "Ranitidine" comes here. What are these pills for, and how to take them correctly?
What helps "ranitidine"?
By its nature, the drug is an antihistamine, but the real scope of its action is somewhat different from simply suppressing the manifestations of allergy. The active substance - ranitidine hydrochloride - inhibits the H2-receptors in the gastric mucosa, and also reduces the production of hydrochloric acid and affects the acidity, reducing its level. Thus, the pharmacology of "Ranitidine" is an anti-ulcer medication that allows to relieve the acute symptoms of any lesions of the gastric mucosa: both with gastroduodenitis and with an ulcer.
- The dosage of the active substance per 1 tablet is 150 and 300 mg.
- After taking 150 mg (single dose), the effect lasts for 12 hours, the maximum concentration is observed 3 hours after ingestion, while eating food does not affect these indicators.
Ranitidine (as a substance) actively penetrates into breast milk, and can also affect the level of prolactin (temporarily), if it is administered by intravenous injection. The duration of elimination depends on the renal function.
Indications and contraindications to "Ranitidine"
The general focus of this drug is any ulcerative lesions of the mucous membrane, both in chronic and in acute form. "Ranitidine" is indicated for:
- prevention of peptic ulcer after surgery and stress;
- treatment of Zollinger-Ellson syndrome, esophagitis, ulcerative lesions of the gastrointestinal tract.
Despite the fact that the active ingredient is fairly safe, there are a number of restrictions on taking the drug. "Ranitidine" is not recommended for pregnant and lactating women, as well as for children under 12 years of age, persons with impaired renal function and cirrhosis of the liver. In addition, doctors note several other nuances associated with therapy and a single use of the drug.
- Since Ranitidine relieves acute manifestations of ulcers, it should be applied only after determining the diagnosis: otherwise, there is a risk of not seeing the development of gastric carcinoma or other diseases that have symptoms similar to peptic ulcer.
- Long-term therapy should not be carried out in persons undergoing severe stress and in need of recovery, since the mucous membrane of the upper gastrointestinal tract may be affected, which would have the opposite effect.
- Ranitidine comes into conflict with ketoconazole and itraconazole, as a result of which they are spread in receptions for 2-3 hours. In addition, it is undesirable to combine this element with pentogastrin and histamine. Also, therapy based on it requires adhering to a diet that is gentle to the stomach and intestines: elimination of spicy, salted, smoked, etc. It is desirable to abandon nicotine, because it reduces the effectiveness of treatment.
The influence of "Ranitidine" on the central nervous system is extremely rarely observed - the concentration and the rate of reaction decrease.
How to take ranitidine?
Taking the drug does not depend on the fullness of the stomach and intestines, so the tablet can be taken both during the meal and after. Chewing it is undesirable, but be sure to drink a large amount of liquid at room temperature. The dosage is calculated depending on the purpose of treatment.
- With the preventive purpose, "Ranitidine" is drunk 1 tablet of 150 mg no more than 2 times a day, the course varies from 14 to 56 days.
- Treatment of peptic ulcer is carried out for 10-12 weeks, during which, in the morning and in the evening, 150 mg of the drug are taken, or 300 mg are drunk at night.
- In the period of preparation for anesthesia for Mendelssohn's syndrome, they drink no more than 150 mg 1.5-2 hours before it. You can additionally take the same day before the operation.
- In case of kidney disorders, it is undesirable to exceed the daily dosage of 150 mg.
- The maximum adult dose is 6 g, used for intravenous administration in order to relieve an acute symptom. With long-term treatment for the day it is undesirable to drink more than 300 mg.
Adverse reactions to "Ranitidine" recorded by the nervous, digestive, cardiovascular systems. It is also possible the manifestation of allergies on the skin, problems of the musculoskeletal system and respiration. Overdose causes convulsions.
Due to the fact that Ranitidine is released only by a specialist’s prescription, if the instructions are followed, the likelihood of a negative reaction to it decreases, but doctors still recommend monitoring the condition of the body in the first days, and if any side effects occur, seek treatment adjustment.