A timely blood test can prevent many serious illnesses. Excess or, on the contrary, a sharp decrease in any indicators will tell a specialist about abnormalities in the body and will help to make a diagnosis correctly and in time. But the patient himself will be completely useful to know what certain indicators mean, for example, gamma-glutamyl transpeptidase, or GGT. If GGT is elevated, the reasons and treatment will be determined by the doctor, but it’s worth knowing what is happening.
GGTP: what to look for?
The gamma-glutamyl transpeptidase enzyme is produced by the human body and is found in the kidneys, liver, bile ducts, muscles (including the heart), the spleen and other organs, participating in amino acid metabolism. A small amount of GGTP is constantly present in the blood, which is not a pathology. GGTP analysis - what is it?
In the biochemical analysis of blood, GGTP values may fluctuate, normal values vary depending on gender, age, and the presence of concomitant diseases. But, despite the fact that the enzyme is most active in the kidneys, an increase in its serum levels indicates violations of the liver. It is considered a marker of cholestasis, the activity of the enzyme is closely related to impaired functioning of the hepatobiliary system. This fact is considered more reliable than ALT and AST in some diseases.
The intensity of the enzyme provoke some drugs taken in large doses, as well as alcohol. To determine the level of GGTP, a blood test is taken on an empty stomach; 24 hours prior to taking blood from a patient's food, fatty foods and alcohol are excluded, which can substantially distort the clinical picture. You should rest, avoiding heavy loads and notify your doctor about medications taken.
Diseases in which GGTP rises
- Cholestasis - a decrease in the amount of bile entering the duodenum or a complete cessation. Bile does not reach the intestines, but bilirubin in the blood is toxic to the body;
- Hemolytic jaundice, as a result of cholestasis;
- Liver cirrhosis is an irreversible replacement of the functional liver parenchyma with fibrous tissue;
- Hepatitis is an inflammation of the liver tissue;
- Neoplasms, including malignant;
- Inflammatory processes in the kidneys;
- Result of injury;
- Poisoning with drugs or alcohol.
Standards standards for the content of the enzyme GGTP
Indicators of the norm of GGT can vary in healthy people, they depend on age, gender, lifestyle, and concomitant diseases.
In newborns, the GGTP enzyme values in the blood are very high, they are several times higher than the norm of an adult. This is due to the peculiarities of the exchange.
- A newborn child is allowed to have a GGT content of up to 185 U / l.
- Up to half a year, this figure may still grow and amount to 200 U / l.
- In a child between 6 months and a year, the rate drops sharply; it should not exceed 34 U / l.
- From one year to three, the figure should not rise above 18 U / l.
- Up to six years, the rate is within 23 U / l.
- A child over six years old and up to twelve normally has indicators of up to 17 U / l.
- Further indicators differ for men and women:
- for girls from twelve to seventeen, the norm should not exceed 32U / l, older than seventeen - 33.
- for guys up to seventeen years old, rates are slightly higher - up to 45 U / l, and for older men - up to 49 U / l.
It is not necessary to wait for unpleasant alarming "bells" to make a biochemical analysis of blood, it can be taken as part of the annual medical examination. It must be remembered that the proper preparation for the analysis is very important, as well as its correct decoding. Do not be afraid of the analysis numbers in advance, before visiting the doctor, as the norms may differ in different laboratories. However, one should not let the control over one's health take place. Timely diagnosis will help to stop the disease at the initial stage and avoid serious consequences.