If you come to the doctor with complaints of pain in the stomach, bouts of nausea, periodic vomiting, bloating, rumbling in the abdomen and besides, you will have a bluish complexion, you will most likely receive a urine diastasis test. The rate in adults depends on age. Its excess indicates a big problem with the digestive tract. How to decipher such an analysis?
Analysis without secrets: urinary diastasis - what is it when checked?
Enzymes are needed to digest food. Diastase (also known as alpha-amylase) is one of them. He is directly involved in the processing of food, namely, in the breakdown of carbohydrates. It produces pancreas and salivary glands. Diastase enters the digestive tract, kidneys, and then urine.
If something is wrong with the digestive system, suspected diseases of the pancreas or other organs involved in the process of digesting food, it will be necessary to pass urine (or blood) to determine the level of amylase. And it is extremely bad if it turns out that its content is above the normal rate. Most often, such a survey is resorted to if symptoms of pancreatitis, peritonitis or diabetes mellitus are detected. The analysis will confirm or refute such diagnoses.
It should be immediately noted that the concept of the norm in this case is only a guideline, because different versions of the standard can be used in different laboratories. In addition, the doctor will make a verdict not only on the basis of the volume of the enzyme, but also taking into account the patient’s condition and other examinations.
But what should urine diastasis be? The rate in adults varies within these limits:
- adults - from 20 to 124 units / l;
- elderly people - 25-160 units / l;
- children - 10-64 units / l.
The standard level of pancreatic alpha-amylase is indicators that do not exceed 50 u / l.
How much does diastase rise in pancreatitis?
If a person has exacerbated pancreatitis, then diastasis in the urine may increase 250 times! Sometimes its performance reaches 16,000 units / l.
In acute pancreatitis, urinary diastasis increases by 3–10 times already within 24 hours from the onset of an attack. In chronic course, the rate in adults with pancreatitis is exceeded moderately and gradually, over a long period. Then, due to the progression of the destruction of the pancreas, it begins to decline steadily. This is due to the fact that the patient develops a lack of enzyme formation. As a result of the deficiency of these substances, the concentration decreases and becomes less than 16 units / l.
Why does the level increase or decrease?
Indicators above the norm can cause such diseases:
- exacerbation of chronic pancreatitis or acute illness;
- cyst and pancreatic cancer;
- inflammation of the salivary gland;
- intestinal obstruction;
- an attack of appendicitis;
- oncosis in the lungs, thyroid gland, prostate gland, colon, ovaries;
- ectopic pregnancy;
- rupture of the fallopian tube;
- perforation of the duodenum or stomach.
Among these diseases there are very dangerous. But they are not diagnosed only by the number of diastase, so do not immediately assume the worst. In addition, an increase in the enzyme may provoke some drugs (NSAIDs, tetracycline, antitumor agents, epinephrine). Amylase also rises in alcohol poisoning, after an abortion, and in people taking drugs.
Diastase is reduced in such pathologies:
- liver disease - hepatitis.
The analysis will show that diastase does not reach the norm, if a person takes citrates and oxalates. Reduction can provoke toxicosis in pregnant women. The drop in amylase can be observed against the background of blockage of the bile duct, diabetes mellitus or renal failure.
How to collect urine for analysis?
If the gastroenterologist assumes the patient has acute pancreatitis, then he will urgently send the patient to the laboratory and issue a referral marked "cito!". For analysis, a fresh (still warm) portion of urine is needed. This is one of the main conditions for the reliability of the research result, because diastasis tends to collapse very quickly. The settled urine cannot be used for such a diagnosis.
If the tests are scheduled as scheduled, then it is necessary to collect the morning portion of urine and deliver it to the laboratory as soon as possible.
If you want to follow the development of the inflammatory process, the daily monitoring of the amount of diastase is conducted. Urine analysis pass every 3 hours.
Why the result may be erroneous and how to avoid it?
A urinalysis test for diastase sometimes gives false information. What can prevent proper testing? Indicators may change under the influence of such factors:
- taking contraceptives, blood-thinning, diuretic drugs, indometacin, morphine;
- alcohol consumption on the eve of the analysis;
- vaginal discharge in the urine.
In order for the study to show an accurate picture of the pancreas, the genitals should be thoroughly washed before collecting urine. It is also necessary to refrain from the use of alcoholic beverages, taking medications that affect the level of diastase. For the study will need the entire portion of morning urine.
The level of diastase is a kind of marker for the health of internal organs, first of all - pancreas. But never try to decipher such an analysis on your own, let alone make a diagnosis. If deviations from the norm are found, the doctor will definitely prescribe additional diagnostics. And only then the final verdict will be delivered and the treatment strategy chosen.