The action of gestagens and preparations containing them on


The attitude of consumers and some specialists to hormone therapy is extremely negative, however, in some situations it is necessary to resort to it. In addition, not everything is so simple, and in order to understand whether it is worth being afraid of a certain name, it is necessary to “get acquainted” with it. In particular, a thick stratum of gestagens deserves attention, having a huge and invaluable effect on the female body. What is their merit, and why is progestin therapy prescribed?

Progestins - what is it?

This name is commonly understood to be representatives of steroid hormones - progestins.

Under this name, it is commonly understood representatives of steroid hormones - progestins. In the body of a woman, the corpus luteum of the ovaries produces them, and in the expectant mother, the fetus’s placenta. Also, a small proportion of progestin and produces the adrenal cortex. The main task of this hormone, like most of those that are observed in the female body, is to increase the likelihood of fertilization of the egg by introducing the uterus during the secretion phase, as well as ensuring the development of the fetus.

The effect of gestagens on the body is to reduce the risk of hyperplasia and the formation of glandular cysts; in addition, they do not allow the endometrium to be reborn, due to the overwhelming effect on estrogen receptors. Transformation of the secretion and the effect of gestagens on the endometrium are key to preventing the increase of estrogens during menopause, the appearance of cysts in the ovaries, uterine fibroids. It should also be noted that the development of the mammary glands in puberty is also due to gestagens.

  • The main and most well-known representative of progestins is progesterone. Women who want to get pregnant and bear a child pay attention to him, he becomes the catalyst of maternal instinct. The time of its synthesis is from the middle of the menstrual cycle to its end.
  • The initial rate of progesterone in the initial stage is from 0.32 nmol / L to 2.23 nmol / L. During the ovulation period, the values ​​increase to 9.41 nmol / l, and the lower limit is 0.48 nmol / l. With the onset of pregnancy up to the third month inclusive, values ​​up to 468 nmol / l are possible. The ratio of estrogen and progesterone should always be in favor of the latter.

At the initial stage, progesterone deficiency affects only the course of the menstrual cycle.

At the initial stage, a deficiency of progesterone affects only the course of the menstrual cycle (including a change in mood), after - it leads to gynecological diseases, and in its advanced form it causes miscarriages and the inability to become pregnant. However, an excess of gestagens (and progesterone in particular) also adversely affects the female body, leading to anemia and breast tumors.

Indications for the use of gestagens and preparations based on them

If we talk about drugs with gestagen activity, then their main purpose is hormone replacement therapy, which allows to restore the level of asteroid hormones when they are deficient. In addition, progestogens can be discharged to prevent uterine bleeding, and during menopause, they show themselves on the part of a prophylactic against oncology and menopause symptoms - on vegetation, sexual function and the genitourinary system. Regulation of the level of gestagens with the help of medicines based on them allows to prevent weight fluctuations caused by

It is noteworthy that progestin drugs are used to prevent pregnancy.hormonal disorders.

It is noteworthy that progestin drugs are used to prevent pregnancy: progesterone blocks ovulation. In addition, it reduces pain during the menstrual cycle, weakens mood swings and even positively affects high blood pressure. However, high-quality progestin contraceptives should be combined - one-component drugs, according to experts, are less reliable.

In conclusion, it should be noted that progestogens in replacement therapy are still not as well known as synthetic hormones, but they allow the most gentle and competent treatment, since they are a natural product of the production of female ovaries and do not increase the risk of cancer cells in the liver.