Nitroxoline

Nitroxolin UBF is a chemotherapeutic agent that, due to its bactericidal and antifungal activity, alleviates the symptoms of urinary tract infection. It contains nitroxolin (Nitroxolinum), in particular, a derivative of 8-hydroxyquinoline.

Nitroxoline UBF: indications for use

Nitroxoline UBF

Created for:

  1. Short-term treatment of acute infections.
  2. To strengthen the long-term periods of remission of diseases of the lower urinary tract caused by bacteria.
  3. With exacerbation of chronic diseases of the urinary tract caused by microorganisms.
  4. With complications in the case of catheterization and for the purpose of prevention.
  5. Treatment of infected adenoma.

Precautionary measures

If necessary, long-term treatment, it is necessary to monitor liver indicators. In the presence of serious disorders in the kidneys, taking the drug is contraindicated.

Act

Nitroxoline belongs to the group of chemotherapeutic agents, has antibacterial and antifungal properties. Nitroxolin is a derivative of nitroquinoline and chelation of divalent cations (the process of formation of organic-mineral complexes (chelates)).

Taking the drug in therapeutic doses contributes to bactericidal activity against the majority of gram-negative and gram-positive bacteria. The effect of the drug is achieved in the treatment of diseases caused by fungi, for example, Candida species that are pathogenic to humans.

Nitroxoline selectively inhibits the production of bacterial DNA and has the ability to selectively store specific enzymes, in particular RNA polymerase.

As a rule, the following strains are sensitive to the drug: beta - hemolytic streptococcus, Klebsiella oxytocum, blink mogranella, staphylococcus, enterococcus, Proteus mirabilis, common proteus, ureaplasma urealytikum, almost all Candida species, Klebsiella.

The drug successfully eliminates the bacteria that cause such a dangerous disease as tuberculosis, and also completely suppresses mold fungi, in particular dermatophytes.

After oral administration, the active ingredient of the drug is rapidly and almost completely absorbed in the intestine. Strains of coagulase staphylococci can be resistant to the drug, while strains Burkholderia cepacia and Stenotrophomonas maltophilia have an innate resistance to the drug.

After oral administration, nitroxoline is quickly absorbed (within 15-30 minutes). The maximum time is 1-1.5 hours, so a high concentration of the drug is often detected in urine tests, from 100 mg / ml and higher. Plasma protein binding is about 10%. The drug is excreted mainly by the kidneys. In the case of moderate renal failure, elimination occurs more slowly, but this has no effect on the effectiveness of this drug.

Severe renal failure (serum creatinine level)> 2 mg / 100 ml), nitroxoline does not eliminate, and, therefore, does not have any therapeutic effect. In conditions of excessive sweating (for example, a sauna), nitroxoline is released in small quantities.

No studies have been conducted, and interactions with other drugs have not been studied. It is possible that the use of drugs containing high doses of minerals, reduces the effectiveness of nitroxoline.

Nitroxoline

Contraindications

  1. Allergy to the components of the medicinal substance. The drug contains soybean oil. Do not use in case of known hypersensitivity to peanuts and soybeans.
  2. Hypersensitivity to nitroxoline.
  3. Serious kidney disease and kidney failure.
  4. Breast-feeding.
  5. Inflammation of the facial nerve.

Adverse reactions

  1. Nausea, vomiting, diarrhea.
  2. Lack of appetite.
  3. Headache.
  4. Skin redness, itchy skin (infrequently)
  5. Hypersensitivity reactions, thrombocytopenia (sometimes).
  6. Fatigue, constant headache, dizziness, unsteadiness of gait (very rarely).
  7. Heart rhythm disorder.
  8. Polyneuropathy.
  9. Ataxia.
  10. Yellowing of urine, skin, hair, nails and eye sclera (the effect is harmless, disappears after stopping treatment).
  11. Overdose is observed fatigue, without loss of consciousness and orientation.
  12. Neuritis of the optic nerve (with long-term use of the drug).

Pregnancy and breastfeeding

Pregnancy

There is no accurate data on the use of nitroxoline in pregnant women. Based on the available toxicological data, the risk of neurotoxicity to the fetus (embryo) cannot be completely excluded. For this reason, the drug can only be used if absolutely necessary, and an individual assessment of nitroxoline resistance based on susceptibility testing should be considered. There is no complete information about the excretion of the drug in milk, so do not use it during breastfeeding.

Adult Dosage

It is applied inside. For adults, the recommended dose is 1 capsule in 3 doses for 24 hours. The drug should be taken before main meals. When hypersensitivity of the stomach is used in 1-2 hours after eating.

-

Dosage for children

It is allowed to take the drug for children over 5 years old, but not more than 0.4 g (4 tablets) per day. The dose is divided into 4 parts and taken at 0, 1 g at a time. Dose can be reduced by half.

Children from 5 to 15 years are advised to take 0.5-1g 4 times.

Children over 15 years old are equal to adults, and their dose is 2 tablets four times a day, but not longer than 3 weeks.

A repeated course of the drug is prescribed if the chronic infection progresses. Between courses of treatment - an interval of two weeks.

How to treat cystitis with nitroxoline?

cystitis nitroxoline

Nitroxoline is perhaps the most effective remedy for the treatment of cystitis from all existing drugs.

This pathology is purely bacterial in nature, but can be caused by a viral or fungal infection. Reviews of nitroxoline in cystitis show the disease is easily stopped, if you follow the scheme and recommendations of the doctor.

Pregnant women and lactating mothers who suffer from cystitis, the use of this drug is prohibited, as it can lead to abnormalities in the development of the fetus. Ingestion of the drug in milk during breastfeeding is also undesirable.

If there are concomitant diseases, such as: cataract, inflammation of the liver and kidneys, the use of nitroxoline is also undesirable.

Nitroxoline: analogues

Amiloride is an antimicrobial drug that acts as a diuretic, increases the excretion of sodium ions and water from the body, removes excessive excretion of potassium.

The initial effect of the drug is observed after 2 hours, the maximum effect after 6-10 hours. The total duration of action is about 24 hours. 50% is excreted in the urine through the kidneys.

Dioxidine - has a synthetic origin, has a wide spectrum of antimicrobial action. Available in the form of ointment and solution.

Analogs of nitroxoline are also:

  • 5 - Nitrox;
  • 5 - NOC;
  • Syvox;
  • nitroxoline - AKOS.

Before taking nitroxoline, you should see a doctor. This manual is intended for informational purposes only. For more information, please read the manufacturer's annotation.

Add a comment